SynVivo is a spin-out company from CFD Research that has developed 3D tissue/organ-on-chip models that accelerate real-time studies of cellular behavior, drug delivery and drug discovery by providing a biologically realistic microenvironment that more accurately depicts in vivo reality. SynVivo models recreate complex in vivo microvasculature including scale, morphology, hemodynamic shear stress and cellular interactions in an in vitro microfluidic chip environment. These tissue models are both morphologically and physiologically realistic with side-by-side architecture enabling real-time visualization and quantitation.
SynBBB: Recreate normal and dysfunctional blood brain barrier models.
- Accurate in vivo hemodynamic shear stress
- Real-time visualization of drug transport, cellular and barrier functionality
- Compatible with standard analytical instrumentation
SynTumor: Recreate the tumor microenvironment.
- Side by side architecture enables quantitative real-time visualization
- Physiological leaky vasculature with engineered porous structures
- Morphologically realistic in vivo based architecture
- Monitor interactions between tumor, stromal, vascular and immune cells
SynRAM: Simultaneously visualize rolling, adhesion and migration in a single experiment
- Physiological flow within a microvascular environment
- In vivo like vascular morphology with fully formed lumen
- Co-culture capability for cell-cell interactions
- Quantitative real-time rolling, adhesion, and migration data from a single experiment
SynTox: Evaluate candidate drugs for organ specific toxicity responses
- Physiologically realistic vascular and tissue cell interactions
- Universal platform to model architecture specific to desired organs
- Real time monitoring of cellular responses
- Compatible with standard analytical instruments for both on chip and off chip assays including omic methodologies
Go to www.synvivobio.com for more information or to order products and inquire about services.
